Synthesis, Characterization and Antimicrobial Activity of Metal Complexes of N-(4-methoxybenzylidene) Isonicotinohydrazone Schiff Base

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Md. Sajjad Hossain
Farzana Khanm Camellia
Nayon Uddin
Md. Kudrat-E-Zahan
Laila Arjuman Banu
Md. Masuqul Haque

Abstract

Two complexes of Cu(II) and Ni(II) with the ligand N- (4-methoxybenzylidene) isonicotinohydrazide, having the formula [M(La)2]2+ (M = Cu(II) and Ni(II)) were synthesized. The ligand was synthesized by the condensation of isonicotinic acid hydrazide (isoniazid) with 4- methoxybenzaldehyde (p- anisaldehyde). The complexes were characterized by FTIR, UV-Vis spectroscopy, molar conductivity, magnetic susceptibility and evaluated for their in vitro antibacterial activity against human pathogens like gram negative Escherichia coli (E. coli) and gram positive Bacillus cereus (B. cereus)strains. The results indicate that all complexes consist of N and O coordination with metals has better antimicrobial activity.

Keywords:
Schiff base ligands, Cu(II) and Ni(II), isoniazid, antimicrobial activity

Article Details

How to Cite
Hossain, M. S., Camellia, F., Uddin, N., Kudrat-E-Zahan, M., Banu, L., & Haque, M. (2019). Synthesis, Characterization and Antimicrobial Activity of Metal Complexes of N-(4-methoxybenzylidene) Isonicotinohydrazone Schiff Base. Asian Journal of Chemical Sciences, 6(1), 1-8. https://doi.org/10.9734/ajocs/2019/v6i118987
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Original Research Article