Recent Advances in Chalcones: Synthesis, Transformation and Pharmacological Activities

Main Article Content

Oluwaseyi Bukky Ovonramwen
Bodunde Joseph Owolabi
Amowie Philip Oviawe

Abstract

Chalcones are useful intermediates in the synthesis of heterocyclic compound and the unique reagents in organic synthesis. The usual approach to obtain chalcones is through Claisen-Schmidt condensation. Several novel heterocyclic chalcone analogs have emerged. Chalcones are multifunctional molecules that possess promising pharmacological activities. Chalcones are known for anti-cancer, antioxidant, anti-inflammatory, anti-microbial, anti-tubercular, antileishmanial, antimalarial, anthelmintic, osteogenic activities. This review article focuses on recent applications of Claisen-Schmidt condensation reaction employed in the synthesis of chalcone, its transformation to heterocyclic compounds and pharmacological activities.

Keywords:
Chalcone, heterocycles, synthesis, pharmacological activities.

Article Details

How to Cite
Ovonramwen, O., Owolabi, B., & Oviawe, A. (2019). Recent Advances in Chalcones: Synthesis, Transformation and Pharmacological Activities. Asian Journal of Chemical Sciences, 6(3), 1-16. https://doi.org/10.9734/ajocs/2019/v6i318996
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