Synthesis, Spectral Characterization, DNA Binding, Cleavage and Biological Evaluation on Co(II), Ni(II) and Cu(II) Complexes of Substituted Isoxazole Schiff Bases

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Gali Ramesh
Marri Pradeep Kumar
Aveli Rambabu
Narendrula Vamsikrishna
Sreenu Daravath
Shivaraj .

Abstract

A series of [Co(LI)2] (1), [Ni(LI)2] (2), [Cu(LI)2] (3), [Co(LII)2] (4), [Ni(LII)2] (5) and [Cu(LII)2] (6) complexes where LI = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-5-methoxyphenol and LII = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-4-bromophenol, were synthesized and characterized by elemental analysis, Infrared, UV–visible, Nuclear magnetic resonance, Mass spectral studies, Electron Spin Resonance, Thermogravimetric analysis, Magnetic moment, Scanning Electron Microscope and Powder X-ray Diffraction analyses. From the analytical results, all these metal (II) complexes are assigned to square planar geometry around the metal ions. The DNA-binding and cleavage studies were evaluated for the synthesized compounds with CT–DNA and supercoiled pBR322 DNA, respectively. All compounds have been monitored for their in Vitro antimicrobial assay.

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Keywords:
Schiff base, transition-metal (II) complex, DNA interaction, biological activity

Article Details

How to Cite
Ramesh, G., Pradeep Kumar, M., Rambabu, A., Vamsikrishna, N., Daravath, S., & ., S. (2018). Synthesis, Spectral Characterization, DNA Binding, Cleavage and Biological Evaluation on Co(II), Ni(II) and Cu(II) Complexes of Substituted Isoxazole Schiff Bases. Asian Journal of Chemical Sciences, 4(3), 1-20. https://doi.org/10.9734/AJOCS/2018/41465
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Original Research Article