Asian Journal of Chemical Sciences <p style="text-align: justify;"><strong>Asian Journal of Chemical Sciences (ISSN: 2456-7795)</strong> aims to publish high quality papers (<a href="/index.php/AJOCS/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of Chemical Sciences. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer reviewed, open access INTERNATIONAL journal.&nbsp;</p> en-US (Asian Journal of Chemical Sciences) (Asian Journal of Chemical Sciences) Sat, 21 Sep 2019 10:35:42 +0000 OJS 60 Recent Advances in Chalcones: Synthesis, Transformation and Pharmacological Activities <p>Chalcones are useful intermediates in the synthesis of heterocyclic compound and the unique reagents in organic synthesis. The usual approach to obtain chalcones is through Claisen-Schmidt condensation. Several novel heterocyclic chalcone analogs have emerged. Chalcones are multifunctional molecules that possess promising pharmacological activities. Chalcones are known for anti-cancer, antioxidant, anti-inflammatory, anti-microbial, anti-tubercular, antileishmanial, antimalarial, anthelmintic, osteogenic activities. This review article focuses on recent applications of Claisen-Schmidt condensation reaction employed in the synthesis of chalcone, its transformation to heterocyclic compounds and pharmacological activities.</p> Oluwaseyi Bukky Ovonramwen, Bodunde Joseph Owolabi, Amowie Philip Oviawe ##submission.copyrightStatement## Sat, 21 Sep 2019 00:00:00 +0000 Phytochemical Study and Biological Activities of Two Medicinal Plants used in Burkina Faso: Lannea velutina A. Rich (Anacardiaceae) and Ximenia americana L. (Olacaceae) <p><strong>Background:</strong> Bacterial infections are at the origin of a number of serious pathologies, including meningitis, bronchopneumopathies, typhoid fever and especially diarrhea, which are still a real public health problem for the child population in developing countries. In most of these countries, people use medicinal plants for primary health care. The objective of this study was to determine the content of phenolic compounds, the antioxidant and antimicrobial activity of extracts from two plants used in traditional medicine in Burkina Faso, <em>Lannea velutina and Ximenia americana.</em></p> <p><strong>Place and Duration of Study</strong><strong>:</strong> Laboratory of Biochemistry and Applied Chemistry (LABIOCA).</p> <p><strong>Methods:</strong> The total phenolics and flavonoid content of the ethanolic extract extracts were determined by spectrometric assay. The DPPH and FRAP method were used to measure the antioxidant capacity of the extracts. The antibacterial potential was determined on five bacterial strains.</p> <p><strong>Results</strong><strong>:</strong> The ethanolic extracts of <em>Lannea velutina</em> showed the best polyphenol content with 969.67±8.23 ​​mgGAE/g extract against 753.145917±66.31 mgGAE/g extract for <em>Ximenia americana.</em> On the DPPH radical <em>Ximenia americana</em> gave the best activity with a percentage inhibition of 62.32±0.17% compared to <em>Lannea velutina</em>. This species also gave the best reducing activity with a reducing capacity of 3.45±0.97 mmol EAA/10 g of extract. <em>Shigella dysenteria</em> and <em>Staphylococcus aureus</em> were susceptible to <em>Lannea velutina</em> and <em>Ximenia americana</em> with inhibition diameters greater than 8 mm.</p> <p><strong>Conclusion:</strong> These results showed that the extract has good antioxidant potential as well as antimicrobial activity. These extracts could be used to prevent damage from oxidative stress and infections.</p> Dramane Pare, Jotham Yhi-pênê N’do, Samson Guenne, Mahamadi Nikiema, Adama Hilou ##submission.copyrightStatement## Sat, 28 Sep 2019 00:00:00 +0000 Evaluation of the Chemical and Oil Composition of Balsam Apple (Momordica balsamina) seed <p>This research is aimed at the proximate chemical analysis of Momordica balsamina seeds with some properties of the oil. The results of the study showed that the seeds has high percentage of crude lipids, (38.77±0.15%) crude carbohydrates, (31.46±0.14%), crude proteins, (20.25±0.10%), moisture content, (5.25±0.25) and crude fibre, (1.67±0.20) as the least, with calorific value of (486.22Kcal) and some selected minerals Na, Mg, Ca, Fe with the concentration, 7.5, 61.5, 42, and 6.2(mg/100 g) respectively. So also, the oil indicated to have acid value of 0.426 and Saponification value of 183.4.Hence Momordica balsamina seeds could be a good source of food supplement.</p> B. I. Yerima, A. Umar ##submission.copyrightStatement## Fri, 18 Oct 2019 00:00:00 +0000 Gamma Irradiated Synthesis of Polyethylene Oxide (PEO)-N, N-Dimethyacrylamide (DMA) Hydrogel and Chitosan <p>Hydrogel which can swell rapidly and retain large volumes of water in their swollen structure have shown a significant contribution for wound healing. More recently, hydrogel synthesized by radiation polymerization and grafting have been reported which did not require any crosslinking agent. In this study, Crosslinked Poly ethylene oxide (PEO) / N, N-dimethylacrylamide (DMA) hydrogel containing chitosan for wound dressing has been prepared by gamma radiation technique. Chitosan solutions with different concentration (0.5-1.5%,10%) have been blended with 5% aqueous solution of Poly ethylene oxide, N, N-dimethylacrylamide and irradiated at the doses 5-20 kGy by gamma rays. The copolymers were characterized by Fourier transform infra-red spectroscopy and their physical chemical properties of hydrogels were evaluated in terms of gel fraction, swelling ratio, elongation at break and mechanical properties (tensile Strength). It was found that under maximum condition of incorporation 1% chitosan with irradiation dose of 10 kGy, Poly ethylene oxide - N, N-dimethylacrylamide -chitosan hydrogels with high gel fraction (80%), swelling ratio (4152%) and elongation at break (110%) were obtained.&nbsp;</p> Sony Ahmed, Milon Bhoumik, Shafiul Islam, Saurav Shuvo ##submission.copyrightStatement## Tue, 22 Oct 2019 00:00:00 +0000 Drug Excipient Compatibility Testing Protocols and Charaterization: A Review <p>Drug molecule contains various reactive functional groups which are susceptible to react with another reactive functional groups which might be excipients, excipient or drugs impurities formed during manufacturing or storage. The objective of the current review article is to provide a comprehensive review of excipients-drug compatibility study, their degradation product characterization with different analytical methods and further impact of methodologies in pharmaceutical industry for potential stability assessment. The incompatibility of drug excipient was very common due to the reactive functional groups in drugs and excipients. These leads to formation of drug related impurities as well as excipient impurities reaction with active Pharmaceutical Ingredients. Sometimes these impurities found to be mutagenic and genotaxic to human beings. Identification of drug degradation in presence of excipient impurities requires extensive knowledge and adequate analytical characterization data. Systematic literature review and understanding about the drug-excipient chemistry in formulation process is important criteria to select compatible excipient and formulate ideal formulation. The analytical characterization data gives idea about degradation pathway. This paper discusses drug-excipient interactions, compatibility and characterization by different analytical methods with case studies and provides an overview of different excipients compatibility in formulation.</p> Krishna R. Gupta, Anita R. Pounikar, Milind J. Umekar ##submission.copyrightStatement## Tue, 22 Oct 2019 00:00:00 +0000