Antimicrobial Activities of Co (III), Mono and Tri-nuclear Ni Complexes Containing Schiff base Functionalized Imidazolium based Ligands
Asian Journal of Chemical Sciences,
We reported the antimicrobial activities of cobalt and nickel complexes containing imino-NHC ligands. Complex 2 was synthesized by direct reaction of the insitu generated free carbene from 2-[2-(3-benzylimidazol-1-yl)ethyliminomethyl]phenol ligand with NiCl2 diglyme while complexes 3-5 were previously reported as catalysts in the transfer hydrogenation reaction of ketones. The compounds 1-5 were screened for antimicrobial sensitivity test against four gram-negative bacteria Escherichia Coli (E-coli), Shigella, Klebsiella Pneumoniae (K. Pneumoniae) and Salmonella Typhi (S.Typhi) and a gram positive bacteria Staphylocossus aureus (S.aureus). At a varying concentrations of 100, 200, 300, 400 and 500 µg/mL, significant activities were recorded using disc diffusion methods. The cobalt complex 3 was found to have higher activities compared with the corresponding nickel complexes and among the three nickel complexes, nickel complex with pyridine as wingtip was found to be more active than the one with a benzyl group. Similarly, the nickel centre with mononuclear was found to be more active than the tri-nuclear nickel complex. Except for the cobalt complex 3 no activity was recorded against S. typhi for all the nickel compounds.
- Schiff base
- N-heterocyclic carbene
- antimicrobial activities
- nickel complex
- cobalt complex
How to Cite
Porchia M, Pellei M, Marinelli M, Tisato F, Del Bello F, Santini C. New insights in Au-NHCs complexes as anticancer agents. European Journal of Medicinal Chemistry. 2018;146:709-746.
Oehninger L, Rubbiani R, Ott I. N-heterocyclic carbenemetal complexes in medicinal chemistry. Dalton Transactions. 2013;42 (10):3269-3284.
Arnold PL, Pearson S. Abnormal N-heterocyclic carbenes. Coordination Chemistry Reviews. 2007;251(5):596-609.
Peris E. Smart N-heterocyclic carbene Ligands in Catalysis. Chemical Reviews. 2018;118(19):9988-10031.
Power PP. Main-group elements as transition metals. Nature. 2010;463:171.
Hansmann MM, Bertrand G. Transition-Metal-like Behavior of Main Group Elements: Ligand Exchange at a Phosphinidene. Journal of the American Chemical Society. 2016;138(49): 15885-15888.
Arnold PL, Mungur SA, Blake AJ, Wilson C. Anionic Amido N-heterocyclic carbenes: Synthesis of Covalently Tethered Lanthanide–Carbene Complexes. Angewandte Chemie. 2003; 115(48): 6163-6166.
Brendel M, Wenz J, Shishkov IV, Rominger F, Hofmann P. Lithium Complexes of Neutral Bis-NHC Ligands. Organometallics. 2015;34(3):669-672.
Gupta KC, Sutar AK. Catalytic activities of Schiff base transition metal complexes. Coordination Chemistry Reviews. 2008; 252 (12):1420-1450.
Abubakar S, Bala MD. Application of Ni(II) complexes of air-stable Schiff base functionalized N-heterocyclic carbene ligands as catalysts for the transfer hydrogenation of aliphatic ketones. Journal of Coordination Chemistry. 2018;71: 2913-2923.
Abubakar S, Ibrahim H, Bala MD. Transfer hydrogenation of ketones catalyzed by a trinuclear Ni(II) complex of a Schiff base functionalized N-heterocyclic carbene ligand. Inorganica Chimica Acta. 2019;484:276-282.
Nirmala M, Prakash G, Ramachandran R, Viswanathamurthi P, Malecki JG, Linert W .Nickel(II) complex incorporating methylene bridged tetradentate dicarbene ligand as an efficient catalyst toward CC and CN bond formation reactions. Journal of Molecular Catalysis A: Chemical. 2015; 397:56-67.
Balouiri M, Sadiki M, Koraichi SI. Methods for in vitro evaluating antimicrobial activity: A review. Journal of Pharmaceutical Analysis. 2016;6:71–79.
Jones RN, Barry AL, Gavan TL, Washington IIJA. In: Lennette, E.H. Ballows, A. Hausler, WJ, Shadomy HJ (Eds.). Manual of Clinical Micro- biology. American Society for Micro-biology, Washington DC. 1985;972 (4th edn).
El-Ayaan U, Abdel-Aziz AM. Synthesis, antimicrobial activity and molecular modelling of cobalt and nickel complexes containing the bulky ligand: bis[N-(2,6 diisopropylphenyl) imino] acenaphthene. European Journal of Medicinal Chemistry. 2005;40:1214–1221.
Raman N, Muthuraj V, Ravichandran S, Kulandaisamy A. Proceedings of the Indian Academy of Science. 2003;115: 161.
Abstract View: 188 times
PDF Download: 57 times