Metal Complexes of Gatifloxacin: Synthesis, Characterization and Evaluation of Biological Activity
Asian Journal of Chemical Sciences,
The antibiotic agent Gatifloxacin is well known for its drug design and coordinating ability towards metal ions. In this paper, synthesis and biological activity of Mn(II), Co(II), Ni(II), Cu(II) and Mg(II) complexes of gatifloxacin is reported. Ligand is itself prepared using o-phenylenediamine (OPD) and 3-acetyl coumarin. The structure of complexes has been investigated using some physiochemical and spectroscopic techniques. In vitro evaluation of these complexes was also carried out for antibacterial and antimicrobial activity. Some complexes exhibited promising anti-bacterial and antimicrobial activity compared to gatifloxacin drug.
- drug-metal complexes
- coumarine derivatives
- antimicrobial activity
How to Cite
Dartmouth Toxic Metal Research Facility.
OSHA. Safety and Health Topics: Toxic Metals.
Avaialble: http://www.osha.gov / SLTC / metalsheavy /index.html
Muthusamy Selvaganapathy and Natarajan Raman; “Pharmacological Activity of a Few Transition Metal Complexes: A Short Review”; J Chem Bio Ther. 2016;Vol 1(2):108
Boerner LJ, Zaleski JM; “Metal complex-DNA interactions: from transcription inhibition to photoactivated cleavage” Current Opinion in Chemical Biology. 9: 135-44. DOI: 10.1016/J.Cbpa.2005.02.010
Andriole VT. The Quinolones, 2nd edn. Academic Press, San Diego, CA; 1998.
Joseph M.Blondeau; “Fluoroquinolones: mechanism of action, classification, and development of resistance”; Survey of Ophthalmology. 2004;49(2), Supplement 2, March:S73-S78 DOI: 10.1016/j.survophthal.2004.01.005
Isenberg HD; “Clinical Microbiology: Past, Present, and Future” J. Clin. Micro.; Dec 2020 Vol.41, No.3; DOI: 10.1128/JCM.41.3.917-918.2003
Drlica K, Malik M, Kerns RJ, Zhao X. “Quinolone-mediated bacterial death”; Antimicrob. Agents Chemother. 2008 Feb;52(2):385-92. DOI: 10.1128/AAC.01617-06
Zeitlinger M, Sauermann R, Fille M, Hausdorfer J, Leitner I, Müller M; “Plasma protein binding of fluoroquinolones affects antimicrobial activity”; Journal of Antimicrobial Chemotherapy, Volume 61, Issue 3, March 2008, Pages 561–567, DOI: 10.1093/jac/dkm524
Lockshon D, Morris DR; “Sites of reaction of Escherichia coli DNA gyrase on pBR322 in vivo as revealed by oxolinic acid-induced plasmid linearization”; J. Mol. Bio. 1985; Jan 5181(1):63–74. DOI: 10.1016/0022-2836(85)90324-9.
Fisher LM, Mizuuchi K, O’Dea MH, Ohmori H, Gellert M; ”Site-specific interaction of DNA gyrase with DNA”. PNAS, July 1, 1981 78 (7) 4165-4169; DOI:10.1073/pnas.78.7.4165.
Capranico G, Binaschi M.; “DNA sequence selectivity of topoisomerases and topoisomerase poisons” Biochim. Biophys. Acta. 1998 Oct 1;1400(1-3):185-94. doi: 10.1016/s0167-4781(98)00135-3
Christopher, Kelly; Christopher, (Xiang) Lee; Nicholas, Leadbeater; “An approach for continuous-flow processing of reactions that involve the in situ formation of organic products”; Tetrahedron Letters; Volume 52,2;12 January 2011:263-265. DOI: 10.1016/j.tetlet.2010.11.027
Clyde Schultz; “Gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitis: safety, efficacy and patient perspective”; Ophthalmol Eye Dis. 2012;4:65–70. DOI: 10.4137/OED.S7383
Vekariya RH, Patel HD; “Recent Advances in the Synthesis of Coumarin Derivatives via Knoevenagel Condensation: A Review” Synthetic Communications Reviews; Volume 44, 2014,19:2756-2788 DOI: 10.1080/00397911.2014.926374
Akkasali Ramachandra, Patil Nirdosh and Angadi SD; “synthesis, characterization and microbial
activities of metal complexes with coumarine derivatives” Rasayan. J Chem; Vol.2, No.1 (2009), 81-86.
Cotton FA, Goodgame DML and Goodgame M; “The Electronic Structures of Tetrahedral Cobalt(II) Complexes” J. Am. Chem. Soc. 1961, 83, 23, 4690–4699. DOI:10.1021/ja01484a002
Kontogiorgis CA and Hadjipavlou-Litina DJ; “Synthesis and Antiinflammatory Activity of Coumarin Derivatives”; J. Med. Chem;. 2005, 48, 20, 6400–6408 DOI: 10.1021/jm0580149
Garbutcheon-Singh, K. B., Grant, M. P., Harper, B. W., Krause-Heuer, A. M., Manohar, M., Orkey, N., and Aldrich-Wright, J. R.; “Transition metal based anticancer drugs” Curr. Top. Med. Chem.; 2011, 11, 521– 542. DOI: 10.2174/156802611794785226
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