A Brief Overview on One Pot Multi-component Synthesis and Biological Properties of a Class of Nitrogenous Complex Heterocyclic Compounds
Sourav Dey
Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India.
Pranab Ghosh *
Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India.
*Author to whom correspondence should be addressed.
Abstract
The quinoline and acridine core possesses a vast number of biological activities such as anticancer, anti-malarial, anti-microbial, antifungal, anti-tubercular activities and the conventional classical synthetic methods have harsh conditions having multistep process. Currently scientists are searching new methodology to eliminate the use of chemicals, solvents and catalysts, which are hazardous to human health as well as to environment and so, this review provides a concise overview of new dimensions of one pot multi-component synthetic approaches in designing quinoline and acridine scaffold. This review would give more scientific ideas to synthesis a variety of heterocyclic moieties in a new synthetic way following the one-pot multi-component method.
Keywords: Quinolines, acridines, 1,4-dihydropyridines, pyrido-pyrimidines, tetrazoloquinazolinones, one-pot reactions, multicomponent synthesis