Asian Journal of Chemical Sciences 2022-08-04T05:37:10+00:00 Asian Journal of Chemical Sciences Open Journal Systems <p><strong>Asian Journal of Chemical Sciences (ISSN: 2456-7795)</strong> aims to publish high quality papers (<a href="/index.php/AJOCS/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of Chemical Sciences. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> <p>This is an open-access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.</p> Bermuda Triangle in Chemistry 2022-07-28T05:01:06+00:00 Dumitru Petru I. Iga D. Popescu V. I. R. Niculescu <p>It is believed that the place called Bermuda triangle is able to hide of human seeing objects entered its area. A Bermuda triangle in chemistry is able to hide (mask) atoms or planar molecular fragments cut by their mirror plane of symmetry, not of human eyes but, of polarized light. A triangular skeleton (frame) has been imagined, possessing the ability to cover many hundreds of molecular formulae, providing the latter refer to aliphatic, or partially aliphatic, compounds, and with a low degree of oxidation. This skeleton (frame) is based on a very general and strong principle, valid in <em>meso</em> entities. The idea is advanced that isomers coming up from a molecular formula could be of four types (groups): <em>meso</em>, C<sub>2</sub> symmetrical (<em>CTS</em>), <em>irrechi</em> (from <em><u>irre</u></em>gular <em><u>chi</u></em>ral) and <em>constitutional </em>(<em>constit.</em>). The following universal rule is revealed: all <em>CTS</em> and <em>irrechi</em> can be converted to <em>meso</em> ones, but the reverse is not true, at least for the same skeleton. At the same time, an impressive number of constitutional natural or synthetic combinations are characterized by at least one real or envisaged <em>meso</em> isomer. Thus, from a structural point of view, <em>meso</em> isomers are justified as reference compounds. The above mentioned principles have been applied to numerous natural compounds: amino acids, lipids, carbohydrates, nucleosides, vitamins, steroids, alkaloids,&nbsp; hydrocarbons. A mathematical equation sustaining the triangular representation has been proposed. One raises the question which of the four types is the upper. A tentative answer is given to this question.</p> 2022-07-25T00:00:00+00:00 ##submission.copyrightStatement## Molecular Docking, Pharmacokinetics and Molecular Dynamics Simulation Studies of Some Bioactive Compounds Isolated from Entandrophragma congoënse for Antiplasmodial Activity 2022-07-26T11:06:00+00:00 Sikiru Akinyeye Ahmed Gervais Mouthé Happi Désiré Soh Shina Salau <p>As a follow-up to earlier reported works on the phytochemical study of some isolated bioactive compounds from the root and bark of <em>Entandrophragma congoënse </em>as potent anti-plasmodium drugs (Happi <em>et. al.</em>2005), some of the isolated compounds were tested <em>in vitro </em>for antiplasmodial and cytotoxicity but no insight was given into the binding affinities of these compounds, the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity), drug-likeness studies as well as molecular dynamics simulation of some of the isolates. Hence, a total of 21 compounds including 19 isolates and 2 standard drugs were computationally studied for antimalarial activity against the target receptor with Protein Data Bank code (PDB code: 5TBO), but only 4 of the isolated compounds (L1, L2, L4 and L15) showed promise potent hits against <em>Plasmodium</em>. The results of molecular docking, ADMET studies and molecular dynamics simulations reveal that compound L15, when isolated, can alone, or together with other qualified compounds such as L1, L2 and L4 provide a better inhibition rating compared to Chloroquine<sup>®</sup> (L21) the FDA-approved drug for the treatment of malaria.</p> 2022-07-22T00:00:00+00:00 ##submission.copyrightStatement## What Principle Governs the Chemical Dynamic/Kinetic Process (2)? 2022-08-04T05:37:10+00:00 Wei-Xing Xu <p>In this work we explored the detail relation between the positive and reverse chemical reaction rates. It is found that the differential relation between the positive and reverse chemical reaction rates is not simple counter relation. Furthermore, it is revealed that the dynamic/kinetic process automatically broke the symmetry of the nature and during the differential process, the positive and reverse chemical reactions allow duplication. The detail odd-even principle has been elucidated in this work.</p> 2022-08-01T00:00:00+00:00 ##submission.copyrightStatement##