Asian Journal of Chemical Sciences

Synthesis, Spectral Characterization, DNA Binding, Cleavage and Biological Evaluation on Co(II), Ni(II) and Cu(II) Complexes of Substituted Isoxazole Schiff Bases

Gali Ramesh

Department of Chemistry, Osmania University, Hyderabad, Telangana−500007, India

Marri Pradeep Kumar

Department of Chemistry, Osmania University, Hyderabad, Telangana−500007, India

Aveli Rambabu

Department of Chemistry, Osmania University, Hyderabad, Telangana−500007, India

Narendrula Vamsikrishna

Department of Chemistry, Osmania University, Hyderabad, Telangana−500007, India

Sreenu Daravath

Department of Chemistry, Osmania University, Hyderabad, Telangana−500007, India

Shivaraj . *

Department of Chemistry, Osmania University, Hyderabad, Telangana−500007, India

*Author to whom correspondence should be addressed.

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Abstract

A series of [Co(L^I)₂] (1), [Ni(L^I)₂] (2), [Cu(L^I)₂] (3), [Co(L^II)₂] (4), [Ni(L^II)₂] (5) and [Cu(L^II)₂] (6) complexes where L^I = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-5-methoxyphenol and L^II = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-4-bromophenol, were synthesized and characterized by elemental analysis, Infrared, UV–visible, Nuclear magnetic resonance, Mass spectral studies, Electron Spin Resonance, Thermogravimetric analysis, Magnetic moment, Scanning Electron Microscope and Powder X-ray Diffraction analyses. From the analytical results, all these metal (II) complexes are assigned to square planar geometry around the metal ions. The DNA-binding and cleavage studies were evaluated for the synthesized compounds with CT–DNA and supercoiled pBR322 DNA, respectively. All compounds have been monitored for their in Vitro antimicrobial assay.

                                                                     

Keywords: Schiff base, transition-metal (II) complex, DNA interaction, biological activity

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