Characterization of the Structure of 2-(4-methyl-2 Phenyl-4, 5-dihydrooxazol-4-ylmethyl)-isoindole-1, 3-dione by 1D, COSY and HSQC 2D NMR Spectroscopy
Khadim Dioukhane
Engineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Younas Aouine
Engineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco and Team of Organic Chemistry and Valorization of Natural Substances, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
Asmae Nakkabi
Laboratory of Chemistry of Materials and Biotechnology of Natural Products, Faculty of Sciences, Moulay Ismail University, Meknes, Morocco.
Salaheddine Boukhssas
Engineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Hassane Faraj
Engineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Anouar Alami
*
Engineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
*Author to whom correspondence should be addressed.
Abstract
The identity of the 2-(4-Methyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl)-isoindole-1,3-dione, previously synthesized in our laboratory, was proven without doubt by means of 1D and 2D NMR spectroscopy. Two-dimensional NMR spectroscopy played a major role. The analysis of the 2D-COSY spectrum of isoindoline-1,3-dione derivative shows a perfect correlation between neighboring protons. Thus, a correlation was noted between the protons of the phthalimide, H(8) and H(9) on the one hand and H(8') and H(9') on the other hand. The analysis of the 2D-HSQC spectrum of the studied compound indicates a faultless correlation between protons and adjacent carbons, and no correlation in the case of all quaternary carbons.
Keywords: Isoindoline, 1,3-dione, 1D NMR, 2D COSY, 2D HSQC