Synthesis, Characterization and Antimicrobial Activity of Metal Complexes of N-(4-methoxybenzylidene) Isonicotinohydrazone Schiff Base
Md. Sajjad Hossain
Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh.
Farzana Khanm Camellia
Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh.
Nayon Uddin
Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh.
Md. Kudrat-E-Zahan
Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh.
Laila Arjuman Banu
Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh.
Md. Masuqul Haque *
Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Two complexes of Cu(II) and Ni(II) with the ligand N- (4-methoxybenzylidene) isonicotinohydrazide, having the formula [M(La)2]2+ (M = Cu(II) and Ni(II)) were synthesized. The ligand was synthesized by the condensation of isonicotinic acid hydrazide (isoniazid) with 4- methoxybenzaldehyde (p- anisaldehyde). The complexes were characterized by FTIR, UV-Vis spectroscopy, molar conductivity, magnetic susceptibility and evaluated for their in vitro antibacterial activity against human pathogens like gram negative Escherichia coli (E. coli) and gram positive Bacillus cereus (B. cereus)strains. The results indicate that all complexes consist of N and O coordination with metals has better antimicrobial activity.
Keywords: Schiff base ligands, Cu(II) and Ni(II), isoniazid, antimicrobial activity