Isoniazid Derived Schiff Base Metal Complexes: Synthesis, Characterization, Thermal Stability, Antibacterial and Antioxidant Activity Study
Farzana Khanm Camellia *
Department of Chemistry, University of Rajshahi, Rajshahi, 6206, Bangladesh.
Md. Ashrafuzzaman
Department of Chemistry, University of Rajshahi, Rajshahi, 6206, Bangladesh.
Md. Nazrul Islam
Department of Chemistry, University of Rajshahi, Rajshahi, 6206, Bangladesh.
Laila Arjuman Banu
Department of Chemistry, University of Rajshahi, Rajshahi, 6206, Bangladesh.
Md. Kudrat-E- Zahan *
Department of Chemistry, University of Rajshahi, Rajshahi, 6206, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Transition metal complexes of Cu2+, Ni2+ and Co2+ with the Schiff base ligand, N-(2-methoxybenzylidene)isonicotinohydrazone, (L1) were synthesized by the conventional condensation approach. Ligand and its metal were characterized by FT-IR, UV-Vis, Magnetic moment measurements and Thermogravimetric (TGA) analysis. IR spectra revealed that the Schiff base ligand coordinated to the metal ion through nitrogen (N) of azomethine group and oxygen (O) of carbonyl group. IR data coupled with TGA analysis confirmed the presence of coordinated water molecules. Antibacterial activity for both ligand and its complexes were investigated against some pathogenic bacteria and the best activity was observed in the case of the CuL1 against E. coli when compared with standard drug, Kanamycin-30. The antioxidant activity of the CuL1 complex was the greatest among all the complexes when compared to that of BHT.
Keywords: Schiff base, transition metals, isoniazid, Kanamycin-30, antioxidant